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Collaboration Agreements (Collaboration Revenues under the Collaboration Agreement with Takeda) (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Jan. 01, 2021
Oct. 02, 2020
Jul. 03, 2020
Apr. 03, 2020
Jan. 03, 2020
Sep. 27, 2019
Jun. 28, 2019
Mar. 29, 2019
Jan. 01, 2021
Jan. 03, 2020
Dec. 28, 2018
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues $ 270,052 $ 231,092 $ 259,479 $ 226,915 $ 240,310 $ 271,703 $ 240,275 $ 215,487 $ 987,538 $ 967,775 $ 853,826
Collaborative arrangement with Takeda                      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues                 81,672 24,622 18,020
License revenues                      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues                 167,295 165,914 200,272
License revenues | Collaborative arrangement with Takeda                      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues                 61,115 18,112 9,055
Collaboration services revenues                      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues                 78,693 41,911 34,275
Collaboration services revenues | Collaborative arrangement with Takeda                      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                      
Total revenues                 $ 20,557 $ 6,510 $ 8,965