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Collaboration Agreements And Business Development Activities - Takeda Collaboration Narrative (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2021 | Jan. 01, 2021 | Jan. 03, 2020 | Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Milestone payments earned to date | $ 462.5 |  |  |
Collaboration agreement percent of royalty on net sale | 3.00% |  |  |
Remaining performance obligation | $ 87.5 |  |  |
Collaborative arrangement with Takeda |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Sales volume period | 6 years |  |  |
Upfront payments |  |  |  | $ 50.0
Milestone payments earned to date | $ 127.0 |  |  |
Milestone payments earned | 35.0 | $ 66.0 | $ 16.0 |
Maximum amount eligible for commercial milestones under collaborations agreement | 119.0 |  |  |
Amount of revenues recognized included in the beginning contract liability balance | 18.9 |  |  |
Commercial sales milestone | 20.0 |  |  |
Remaining performance obligation | 43.3 |  |  |
Collaborative arrangement with Takeda | Initial |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Royalty tier | $ 300.0 |  |  |
Collaborative arrangement with Takeda | Initial | Minimum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percent of royalty on net sale | 15.00% |  |  |
Collaborative arrangement with Takeda | Initial | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percent of royalty on net sale | 24.00% |  |  |
Collaborative arrangement with Takeda | Final tier | Minimum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percent of royalty on net sale | 20.00% |  |  |
Collaborative arrangement with Takeda | Final tier | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percent of royalty on net sale | 30.00% |  |  |
Collaborative arrangement with Takeda | Japan |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent | 100.00% |  |  |
Collaboration period to achieve specified levels of commercial performance | 2 years |  |  |

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