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Property and Equipment | 12 Months Ended
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Dec. 31, 2021
Property, Plant and Equipment [Abstract] |
Property and Equipment | PROPERTY AND EQUIPMENT Property and equipment consisted of the following (in thousands):
| Estimated Useful Lives |  | December 31,
|  | 2021 |  | 2020
Leasehold improvements | up to 15 years |  | $ | 73,589 |  |  | $ | 40,694 |
Computer equipment and software | 3 years |  | 14,877 |  |  | 18,376 |
Furniture and fixtures | 7 years |  | 15,780 |  |  | 14,931 |
Laboratory equipment | 5 years |  | 23,744 |  |  | 11,707 |
Construction in progress |  |  | 16,872 |  |  | 16,360 |
Total property and equipment |  |  | 144,862 |  |  | 102,068 |
Less: accumulated depreciation |  |  | (40,831) |  |  | (34,684) |
Total property and equipment, net |  |  | $ | 104,031 |  |  | $ | 67,384 |
Depreciation expense was $13.6 million, $9.1 million and $8.3 million during the years ended December 31, 2021, 2020 and 2019, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=120429125&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99779-112916 + Details
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