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Employee Benefit Plans (Tables)
12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Allocated Employee Stock-Based Compensation Expense
We allocated the stock-based compensation expense for our equity incentive plans and our ESPP as follows (in thousands):
 
Year Ended December 31,
 
202120202019
Research and development$46,654 $37,198 $19,374 
Selling, general and administrative73,166 67,872 37,228 
Total stock-based compensation expense$119,820 $105,070 $56,602 
 
Year Ended December 31,
 
202120202019
Stock options$19,048 $19,863 $23,422 
Restricted stock units53,629 35,675 26,056 
Performance stock units43,428 47,106 4,878 
ESPP3,715 2,426 2,246 
Total stock-based compensation expense$119,820 $105,070 $56,602 
Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value The weighted average grant-date fair value per share of stock options and ESPP purchases were as follows:
 
Year Ended December 31,
 
202120202019
Stock options$9.04 $9.44 $8.19 
ESPP$6.12 $6.12 $4.85 
Schedule of Fair Value of Employee Share-Based Payments Awards Stock Option Assumptions and Weighted Average Fair Values
The grant-date fair value of stock option grants and ESPP purchases was estimated using the following assumptions:
 
Year Ended December 31,
 
202120202019
Stock options:
Risk-free interest rate0.74 %0.30 %1.77 %
Dividend yield— %— %— %
Volatility51 %54 %48 %
Expected life4.6 years4.4 years4.3 years
ESPP:
Risk-free interest rate0.08 %0.79 %2.16 %
Dividend yield— %— %— %
Volatility47 %52 %50 %
Expected life6 months6 months6 months
Schedule of Fair Value of Employee Share-Based Payments Awards ESPP Assumptions and Weighted Average Fair Values
The grant-date fair value of stock option grants and ESPP purchases was estimated using the following assumptions:
 
Year Ended December 31,
 
202120202019
Stock options:
Risk-free interest rate0.74 %0.30 %1.77 %
Dividend yield— %— %— %
Volatility51 %54 %48 %
Expected life4.6 years4.4 years4.3 years
ESPP:
Risk-free interest rate0.08 %0.79 %2.16 %
Dividend yield— %— %— %
Volatility47 %52 %50 %
Expected life6 months6 months6 months
Schedule of All Stock Option Activity
Activity for stock options during the year ended December 31, 2021 was as follows (in thousands, except per share amounts):
Shares
Weighted 
Average
Exercise Price
Weighted 
Average
Remaining
Contractual
Term
Aggregate
Intrinsic
Value
Stock options outstanding at December 31, 202016,129 $12.72 
Granted2,573 $21.33 
Exercised(4,486)$4.23 
Cancelled(545)$21.15 
Stock options outstanding at December 31, 202113,671 $16.79 3.3 years$48,860 
Stock options exercisable at December 31, 20219,962 $15.23 2.4 years$48,171 
Schedule of All RSU Activity Activity for RSUs during the year ended December 31, 2021 was as follows (in thousands, except per share amounts):
Shares
Weighted 
Average
Grant Date
Fair Value
Weighted 
Average
Remaining
Contractual 
Term
Aggregate
Intrinsic
Value
RSUs outstanding at December 31, 20205,378 $21.96 
Awarded4,220 $21.34 
Vested and released(2,020)$22.03 
Forfeited(750)$21.69 
RSUs outstanding at December 31, 20216,828 $21.58 1.7 years$124,824 
Activity for PSUs, during the year ended December 31, 2021 was as follows (in thousands, except per share amounts):
Shares
Weighted 
Average
Grant Date
Fair Value
Weighted 
Average
Remaining
Contractual 
Term
Aggregate
Intrinsic
Value
PSUs outstanding at December 31, 20207,378 $21.70 
Awarded2,056 $24.54 
Vested and released(2,388)$19.76 
Forfeited(736)$22.57 
PSUs outstanding at December 31, 20216,310 $23.00 3.0 years$98,121 
Schedule of Share-Based Payment Award, Equity Instruments Other Than Options, Valuation Assumptions A Monte Carlo simulation model was used to determine the grant date fair value of $24.54 for the 2021 PSUs based on the following assumptions:
Fair value of the Company’s common stock on grant date
$21.31 
Expected volatility
49 %
Risk-free interest rate
0.29 %
Dividend yield
— %