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Revenues - Net Product Revenues Disaggregated by Product (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Disaggregation of Revenue [Line Items]      
Net product revenues $ 1,434,970 $ 987,538 $ 967,775
CABOMETYX      
Disaggregation of Revenue [Line Items]      
Net product revenues 1,054,050 718,687 733,421
COMETRIQ      
Disaggregation of Revenue [Line Items]      
Net product revenues 23,206 22,863 26,529
Net product revenues      
Disaggregation of Revenue [Line Items]      
Net product revenues $ 1,077,256 $ 741,550 $ 759,950