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Collaboration Agreements And Business Development Activities - Collaboration Revenues under the Collaboration Agreement with Ipsen (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues $ 1,434,970 $ 987,538 $ 967,775
Collaborative Arrangement with Ipsen      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 302,073 151,631 152,771
License revenues      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 249,956 167,295 165,914
License revenues | Collaborative Arrangement with Ipsen      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 207,982 93,495 117,360
Collaboration services revenues      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 107,758 78,693 41,911
Collaboration services revenues | Collaborative Arrangement with Ipsen      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues $ 94,091 $ 58,136 $ 35,411