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Collaboration Agreements And Business Development Activities - Takeda Collaboration Narrative (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Milestone payments earned to date $ 462.5      
Collaboration agreement percent of royalty on net sale 3.00%      
Remaining performance obligation $ 87.5      
Collaborative arrangement with Takeda        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Sales volume period 6 years      
Upfront payments       $ 50.0
Milestone payments earned to date $ 127.0      
Milestone payments earned 35.0 $ 66.0 $ 16.0  
Maximum amount eligible for commercial milestones under collaborations agreement 119.0      
Amount of revenues recognized included in the beginning contract liability balance 18.9      
Commercial sales milestone 20.0      
Remaining performance obligation 43.3      
Collaborative arrangement with Takeda | Initial        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Royalty tier $ 300.0      
Collaborative arrangement with Takeda | Initial | Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 15.00%      
Collaborative arrangement with Takeda | Initial | Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 24.00%      
Collaborative arrangement with Takeda | Final tier | Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 20.00%      
Collaborative arrangement with Takeda | Final tier | Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 30.00%      
Collaborative arrangement with Takeda | Japan        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Research and development arrangement performed for others, reimbursement for costs incurred, percent 100.00%      
Collaboration period to achieve specified levels of commercial performance 2 years