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Collaboration Agreements And Business Development Activities - Collaboration Revenues under the Collaboration Agreement with Takeda (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues $ 1,434,970 $ 987,538 $ 967,775
Collaborative arrangement with Takeda      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 39,725 81,672 24,622
License revenues      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 249,956 167,295 165,914
License revenues | Collaborative arrangement with Takeda      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 26,058 61,115 18,112
Collaboration services revenues      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 107,758 78,693 41,911
Collaboration services revenues | Collaborative arrangement with Takeda      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues $ 13,667 $ 20,557 $ 6,510