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Collaboration Agreements And Business Development Activities - Other Collaborations Narrative (Details) - USD ($)
 12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues $ 1,434,970,000 $ 987,538,000 $ 967,775,000
Collaborative Arrangement with Genentech | Cotellic      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 12,100,000 11,300,000 10,300,000
Collaboration Agreement with Daiichi Sankyo      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenues 3,800,000 $ 1,300,000 20,100,000
Achieved milestone amount     $ 20,000,000
Maximum amount eligible for development and regulatory milestones $ 90,000,000