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Consolidated Statements of Income - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2021
Jan. 01, 2021
Jan. 03, 2020
Revenues:      
Total revenues $ 1,434,970 $ 987,538 $ 967,775
Operating expenses:      
Cost of goods sold 52,873 36,272 33,097
Research and development 693,716 547,851 336,964
Selling, general and administrative 401,715 293,355 228,244
Total operating expenses 1,148,304 877,478 598,305
Income from operations 286,666 110,060 369,470
Interest income 7,672 19,865 27,959
Other income (expense), net (184) 912 680
Income before income taxes 294,154 130,837 398,109
Provision for income taxes 63,091 19,056 77,097
Net income $ 231,063 $ 111,781 $ 321,012
Net income per share:      
Basic (in dollars per share) $ 0.73 $ 0.36 $ 1.06
Diluted (in dollars per share) $ 0.72 $ 0.35 $ 1.02
Denominator:      
Basic (in shares) 314,884 308,271 302,584
Diluted (in shares) 322,359 318,001 315,009
Net product revenues      
Revenues:      
Total revenues $ 1,077,256 $ 741,550 $ 759,950
License revenues      
Revenues:      
Total revenues 249,956 167,295 165,914
Collaboration services revenues      
Revenues:      
Total revenues $ 107,758 $ 78,693 $ 41,911