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Collaboration Agreements And Business Development Activities - Collaboration Revenues under the Collaboration Agreement with Ipsen (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Oct. 01, 2021
Sep. 30, 2022
Oct. 01, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 411,738 $ 328,423 $ 1,187,145 $ 983,830
Collaborative Arrangement with Ipsen        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 34,818 38,095 131,585 162,822
License revenues        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 34,384 49,694 123,977 116,862
License revenues | Collaborative Arrangement with Ipsen        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 27,607 25,139 103,389 81,246
Collaboration services revenues        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 10,872 15,612 39,344 92,391
Collaboration services revenues | Collaborative Arrangement with Ipsen        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 7,211 $ 12,956 $ 28,196 $ 81,576