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Collaboration Agreements And Business Development Activities - Collaboration Revenues under the Collaboration Agreement with Takeda (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Oct. 01, 2021
Sep. 30, 2022
Oct. 01, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 411,738 $ 328,423 $ 1,187,145 $ 983,830
Collaborative Arrangement with Takeda        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 6,351 22,734 18,903 34,291
License revenues        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 34,384 49,694 123,977 116,862
License revenues | Collaborative Arrangement with Takeda        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 2,690 20,078 7,755 23,476
Collaboration services revenues        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 10,872 15,612 39,344 92,391
Collaboration services revenues | Collaborative Arrangement with Takeda        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 3,661 $ 2,656 $ 11,148 $ 10,815