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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Oct. 01, 2021
Statement of Cash Flows [Abstract]    
Net income $ 212,455 $ 135,897
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization 14,929 11,699
Stock-based compensation 81,718 96,654
Non-cash lease expense 11,931 3,952
Deferred taxes 0 32,365
Other, net 7,390 35,871
Changes in operating assets and liabilities:    
Trade receivables, net 66,890 (20,124)
Inventory (9,836) (26,956)
Prepaid expenses and other assets (35,166) (24,252)
Deferred revenue (3,130) 11,434
Accrued collaboration liabilities (64,976) 13,947
Accounts payable and other liabilities 6,715 33,865
Net cash provided by operating activities 288,920 304,352
Cash flows from investing activities:    
Purchases of property, equipment and other (25,989) (48,265)
Purchases of investments (1,079,411) (1,077,377)
Proceeds from maturities and sales of investments 826,768 1,095,813
Net cash used in investing activities (278,632) (29,829)
Cash flows from financing activities:    
Proceeds from issuance of common stock under equity incentive plans 18,680 18,242
Taxes paid related to net share settlement of equity awards (16,091) (15,049)
Net cash provided by financing activities 2,589 3,193
Net increase in cash, cash equivalents, and restricted cash equivalents 12,877 277,716
Cash, cash equivalents and restricted cash equivalents at beginning of period 663,891 320,772
Cash, cash equivalents and restricted cash equivalents at end of period 676,768 598,488
Non-cash operating activities:    
Right-of-use assets obtained in exchange for lease obligations 121,958 4,893
Non-cash investing activities:    
Unpaid liabilities incurred for purchases of property and equipment 1,643 5,143
Unpaid liabilities incurred in asset acquisition $ 500 $ 9,000