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Collaboration Agreements And Business Development Activities - Takeda Collaboration Narrative (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 30, 2022
Dec. 31, 2021
Jan. 01, 2021
Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Milestone payments earned to date $ 489.5      
Collaboration agreement percent of royalty on net sale 3.00%      
Remaining performance obligation $ 73.0      
Collaborative arrangement with Takeda        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Upfront payments       $ 50.0
Milestone payments earned to date 127.0      
Milestone payments earned 0.0 $ 35.0 $ 66.0  
Maximum amount eligible for commercial milestones under collaborations agreement 119.0      
Remaining performance obligation 37.6      
Collaborative arrangement with Takeda | Initial        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Royalty tier $ 300.0      
Collaborative arrangement with Takeda | Initial | Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 15.00%      
Collaborative arrangement with Takeda | Initial | Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 24.00%      
Collaborative arrangement with Takeda | Final tier | Minimum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 20.00%      
Collaborative arrangement with Takeda | Final tier | Maximum        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Percent of royalty on net sale 30.00%      
Collaborative arrangement with Takeda | Japan        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Research and development arrangement performed for others, reimbursement for costs incurred, percent 100.00%      
Collaboration period to achieve specified levels of commercial performance 2 years