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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 30, 2022
Dec. 31, 2021
Jan. 01, 2021
Cash flows from operating activities:      
Net income $ 182,282 $ 231,063 $ 111,781
Adjustments to reconcile net income to net cash provided by operating activities:      
Depreciation 20,875 13,630 9,141
Stock-based compensation 107,574 119,820 105,070
Non-cash lease expense 18,315 5,332 4,830
Deferred taxes (60,358) 46,529 15,265
Acquired in-process research and development technology 107,250 14,000 0
Other, net (525) 9,443 3,035
Changes in operating assets and liabilities:      
Trade receivables, net 66,849 (122,324) (42,470)
Inventory (11,683) (13,209) (21,897)
Prepaid expenses and other assets (28,259) (39,875) (25,831)
Deferred revenue (2,483) 11,008 (1,051)
Accrued collaboration liabilities (63,065) 70,297 600
Accounts payable and other liabilities 25,842 55,090 50,509
Net cash provided by operating activities 362,614 400,804 208,982
Cash flows from investing activities:      
Purchases of property, equipment and other (27,706) (54,225) (30,345)
Acquired in-process research and development technology (110,750) (10,000) 0
Purchases of investments (1,450,716) (1,357,168) (1,070,269)
Proceeds from maturities and sales of investments 1,064,758 1,378,509 969,399
Net cash used in investing activities (524,414) (42,884) (131,215)
Cash flows from financing activities:      
Proceeds from issuance of common stock under equity incentive and stock purchase plans 23,886 24,307 24,886
Taxes paid related to net share settlement of equity awards (23,300) (39,108) (50,018)
Net cash provided by (used in) financing activities 586 (14,801) (25,132)
Net (decrease) increase in cash, cash equivalents and restricted cash equivalents (161,214) 343,119 52,635
Cash, cash equivalents and restricted cash equivalents at beginning of period 663,891 320,772 268,137
Cash, cash equivalents and restricted cash equivalents at end of period 502,677 663,891 320,772
Supplemental cash flow disclosures:      
Cash paid for taxes 127,870 12,960 4,115
Non-cash operating activities:      
Right-of-use assets obtained in exchange for lease obligations 155,935 4,893 4,017
Non-cash investing activities:      
Accounts receivable for unsettled investment sales $ 0 $ 0 $ 6,180