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Stockholders’ Equity - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended			3 Months Ended				12 Months Ended
	Apr. 30, 2023	Mar. 31, 2022	Mar. 31, 2021	Sep. 29, 2023	Mar. 31, 2023	Sep. 30, 2022	Oct. 01, 2021	Dec. 29, 2023	Dec. 30, 2022	Dec. 31, 2021	Jan. 01, 2021	Jan. 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Maximum potential to vest				50.00%		25.00%	25.00%
Repurchases of common stock								$ 554,870
Exelixis 401(k) Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expenses relating to stock match								$ 13,900	$ 11,700	$ 9,500
March 2023 Repurchase Program
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock repurchase program, authorized amount					$ 550,000
Repurchases of common stock (in shares)								26,200,000
Repurchases of common stock								$ 550,000
January 2024 Repurchase Program | Subsequent Event
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock repurchase program, authorized amount												$ 450,000
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of months following change in control in which an employee was terminated								3 months
Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of months following change in control in which an employee was terminated								15 months
Stock options
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expiration period								7 years
Total unrecognized compensation expense								$ 9,800
Unrecognized compensation expense weighted-average period for recognition								1 year 10 months 24 days
Intrinsic value of options exercised								$ 16,700	36,500	76,000
Cash received from option exercises and purchases under the ESPP								$ 20,800	$ 13,900	$ 14,800
Stock options | Share-based Payment Arrangement, Employee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period								4 years
Stock options | Share-based Payment Arrangement, Nonemployee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period								1 year
Restricted stock units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total unrecognized compensation expense								$ 172,700
Unrecognized compensation expense weighted-average period for recognition								2 years 6 months
Number of awards granted (in shares)								5,028,000
Number of awards (in shares)								11,874,000	11,294,000
Restricted stock units | Share-based Payment Arrangement, Employee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period								4 years
Restricted stock units | Share-based Payment Arrangement, Nonemployee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period								1 year
TSR-Based Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of awards granted (in shares)	800,000	1,000,000
Maximum potential to vest	175.00%	175.00%
TSR-Based Restricted Stock Units | Share-based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Vesting award percentage	50.00%	50.00%
TSR-Based Restricted Stock Units | Share-based Payment Arrangement, Tranche Two
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period	1 year	1 year
ESPP
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares available for grant (in shares)								1,700,000
Discount rate from market value on purchase date (as a percent)								85.00%
Discount rate from market value on offering date (as a percent)								85.00%
Purchase period								6 months
Common stock issued (in shares)								900,000	600,000	500,000
Average price per share (in dollars per share)								$ 14.56	$ 16.63	$ 17.76
Proceeds from employee stock purchase plan								$ 12,700	$ 10,100	$ 9,500
Performance stock units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Unrecognized compensation expense weighted-average period for recognition								1 year 3 months 18 days
Number of awards granted (in shares)			1,000,000					0
Maximum potential to vest			200.00%		100.00%			125.00%			200.00%
Additional shares to be earned (in shares)			2,100,000								4,700,000
Number of shares earned								1,000,000
Number of awards (in shares)								3,891,000	4,964,000
Performance stock units | Achieved
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of awards (in shares)								1,500,000
Performance stock units | Probable
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total unrecognized compensation expense								$ 6,000
Performance stock units | Not Probable
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total unrecognized compensation expense								$ 41,400
Performance stock units | Share-based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Vesting award percentage			50.00%
Performance stock units | Share-based Payment Arrangement, Tranche Two
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period			1 year
Performance Shares, Clinical Trial Results
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of awards granted (in shares)											2,300,000
Amended and Restated 2017 Equity Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares available for grant (in shares)								27,900,000
Reduction in share reserve after stock option or stock appreciation award (in shares)								1
Reduction in share reserve after all other awards (in shares)								2

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