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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 29, 2023
Dec. 30, 2022
Dec. 31, 2021
Jan. 01, 2021
Pay vs Performance Disclosure        
Pay vs Performance Disclosure, Table
Value of Initial Fixed $100
Investment Based On:
Net Income
(millions)
($)
Net Product
Revenues
(millions)
($)(5)
Year
Summary
Compensation
Table Total for
PEO
($)(1)
Compensation
Actually Paid
to PEO
($)(1)(2)
Average
Summary
Compensation
Table Total for
Non-PEO NEOs
($)(1)
Average
Compensation
Actually Paid
to Non-PEO
NEOs
($)(1)(2)
Total
Stockholder
Return
($)(3)
Peer Group
Total
Stockholder
Return
($)(4)
2023
16,423,307
31,702,754
5,505,198
7,804,316
141
121
207.8
1,628.9
2022
16,877,545
16,020,538
5,149,608
5,038,751
94
116
182.3
1,401.2
2021
7,530,431
15,297,662
3,510,384
5,612,040
107
129
231.1
1,077.3
2020
2,349,812
18,565,411
1,237,199
5,878,678
118
129
111.8
741.6
      
Company Selected Measure Name Net Product Revenues      
Named Executive Officers, Footnote Dr. Morrissey was our PEO for each year presented. The individuals comprising the non-PEO NEOs for each year presented
are as follows: (i) for 2023, Mr. Senner, Dr. Aftab, Dr. Peterson, Dr. Goodman and Mr. Hessekiel; (ii) for 2022, Mr. Senner, Dr.
Goodman, Mr. Haley and Mr. Hessekiel; (iii) for 2021, Mr. Senner, Mr. Haley, Mr. Hessekiel, Dr. Peter Lamb and Dr. Gisela M.
Schwab; and (iv) for 2020, Dr. Schwab, Mr. Senner, Mr. Hessekiel and Mr. Haley. 		     
Peer Group Issuers, Footnote Represents the cumulative peer group TSR, weighted according to the respective companies’ stock market capitalization at
the beginning of each period for which a return is indicated. The peer group used for this purpose is the Nasdaq
Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included
in our annual reports for each of the years in the table.
      
PEO Total Compensation Amount $ 16,423,307 $ 16,877,545 $ 7,530,431 $ 2,349,812
PEO Actually Paid Compensation Amount $ 31,702,754 16,020,538 15,297,662 18,565,411
Adjustment To PEO Compensation, Footnote Compensation actually paid, as calculated under the SEC’s rules, requires making certain adjustments to the “Total” column
of the Summary Compensation Table to reflect the exclusion and inclusion of certain amounts for the PEO and the Non-PEO
NEOs; the tables set forth below reflect those adjustments. Equity values in the tables below are calculated in accordance
with FASB ASC Topic 718. Amounts in the “Exclusion of Stock Awards and Options Awards” column of the tables below are
the totals from the “Stock Awards” and “Option Awards” columns set forth in the Summary Compensation Table. The
differences between the amounts in the “Total” column of the Summary Compensation Table and the “compensation
actually paid” are primarily attributable to the appreciation in the price of our common stock and the annual vesting of RSU
and earned PSU awards, as well as the value recognized upon or following achievement of performance targets for the PSU
awards during the year. In addition, with respect to PSU awards granted to the applicable NEOs during fiscal 2020, the grant
date fair values of such awards, as computed in accordance with ASC 718, excluding the estimate of estimated forfeitures,
are based upon the then-probable outcome of the performance conditions, which was $0 for each NEO. For more
information regarding the 2020 PSU awards, please see “Compensation Discussion and Analysis—2023 Compensation
Year
Summary Compensation
Table Total for PEO
($)
Exclusion of Stock Awards
and Options Awards for PEO
($)
Inclusion of Equity Values
for PEO
($)
Compensation Actually
Paid to PEO
($)
2023
16,423,307
(14,259,313)
29,538,760
31,702,754
Year
Average Summary
Compensation Table Total
for Non-PEO NEOs
($)
Average Exclusion of Stock
Awards and Options Awards
for Non-PEO NEOs
($)
Average Inclusion of Equity
Values for Non-PEO NEOs
($)
Average Compensation
Actually Paid to Non-PEO
NEOs
($)
2023
5,505,198
(4,571,569)
6,870,687
7,804,316
      
Non-PEO NEO Average Total Compensation Amount $ 5,505,198 5,149,608 3,510,384 1,237,199
Non-PEO NEO Average Compensation Actually Paid Amount $ 7,804,316 5,038,751 5,612,040 5,878,678
Adjustment to Non-PEO NEO Compensation Footnote Compensation actually paid, as calculated under the SEC’s rules, requires making certain adjustments to the “Total” column
of the Summary Compensation Table to reflect the exclusion and inclusion of certain amounts for the PEO and the Non-PEO
NEOs; the tables set forth below reflect those adjustments. Equity values in the tables below are calculated in accordance
with FASB ASC Topic 718. Amounts in the “Exclusion of Stock Awards and Options Awards” column of the tables below are
the totals from the “Stock Awards” and “Option Awards” columns set forth in the Summary Compensation Table. The
differences between the amounts in the “Total” column of the Summary Compensation Table and the “compensation
actually paid” are primarily attributable to the appreciation in the price of our common stock and the annual vesting of RSU
and earned PSU awards, as well as the value recognized upon or following achievement of performance targets for the PSU
awards during the year. In addition, with respect to PSU awards granted to the applicable NEOs during fiscal 2020, the grant
date fair values of such awards, as computed in accordance with ASC 718, excluding the estimate of estimated forfeitures,
are based upon the then-probable outcome of the performance conditions, which was $0 for each NEO. For more
information regarding the 2020 PSU awards, please see “Compensation Discussion and Analysis—2023 Compensation
Year
Summary Compensation
Table Total for PEO
($)
Exclusion of Stock Awards
and Options Awards for PEO
($)
Inclusion of Equity Values
for PEO
($)
Compensation Actually
Paid to PEO
($)
2023
16,423,307
(14,259,313)
29,538,760
31,702,754
Year
Average Summary
Compensation Table Total
for Non-PEO NEOs
($)
Average Exclusion of Stock
Awards and Options Awards
for Non-PEO NEOs
($)
Average Inclusion of Equity
Values for Non-PEO NEOs
($)
Average Compensation
Actually Paid to Non-PEO
NEOs
($)
2023
5,505,198
(4,571,569)
6,870,687
7,804,316
      
Equity Valuation Assumption Difference, Footnote The amounts in the “Inclusion of Equity Values” columns in the tables above are derived from the amounts set forth in the
following tables:
Year
Year End Fair
Value of Equity
Awards Granted
During Year That
Remained
Outstanding and
Unvested as of
Last Day of Year for
PEO
($)
Year over Year
Change in Fair
Value of
Outstanding and
Unvested Equity
Awards Granted
in Prior Years for
PEO
($)
Fair Value as of
Vesting Date of
Equity Awards
Granted and
Vested During Year
for PEO
($)
Year over Year
Change in Fair
Value of Equity
Awards Granted
in Prior Years that
Vested During Year
for PEO
($)
Fair Value at Last
Day of Prior Year
of Equity Awards
Forfeited During
Year for PEO
($)
Total – Inclusion
of Equity Values for
PEO
($)
2023
18,468,346
8,239,747
—
2,830,667
—
29,538,760
Year
Average Year End
Fair Value of Equity
Awards Granted
During Year That
Remained
Outstanding and
Unvested as of Last
Day of Year for
Non-PEO NEOs
($)
Average Year over
Year Change in Fair
Value of
Outstanding and
Unvested Equity
Awards Granted in
Prior Years for Non-
PEO NEOs
($)
Average Fair Value
as of Vesting Date
of Equity Awards
Granted and Vested
During Year for
Non-PEO NEOs
($)
Average Year over
Year Change in Fair
Value of Equity
Awards Granted in
Prior Years that
Vested During Year
for Non-PEO NEOs
($)
Average Fair Value
at Last Day of Prior
Year of Equity
Awards Forfeited
During Year for
Non-PEO NEOs
($)
Total – Average
Inclusion of Equity
Values for Non-PEO
NEOs
($)
2023
5,152,448
1,717,856
—
525,908
(525,525)
6,870,687
      
Compensation Actually Paid vs. Total Shareholder Return Required Disclosure of the Relationship Between Compensation Actually Paid and Financial Performance Measures
As required by Item 402(v) of Regulation S-K, we are providing the following graphs to illustrate the relationship of the
“compensation actually paid” figures that are included in the pay versus performance tabular disclosure above, to (1)
our cumulative TSR and that of the Nasdaq Biotechnology index, (2) our net income, and (3) our Net Product Revenues,
which is our company-selected measure. In addition, the first graph below further illustrates the relationship between
our TSR and that of the Nasdaq Biotechnology Index. As noted above, “compensation actually paid” for purposes of the
tabular disclosure and the following graphs was calculated in accordance with SEC rules and does not fully represent
the actual final amount of compensation earned by or actually paid to our NEOs during the applicable years. The graph
assumes that $100 was invested on January 3, 2020 in each of our common stock and the Nasdaq Biotechnology Total
Return Index and assumes reinvestment of any dividends.
4208
      
Compensation Actually Paid vs. Net Income
4210
      
Compensation Actually Paid vs. Company Selected Measure
4212
      
Tabular List, Table
Relative TSR
Net Product Revenues
      
Total Shareholder Return Amount $ 141 94 107 118
Peer Group Total Shareholder Return Amount 121 116 129 129
Net Income (Loss) $ 207,800,000 $ 182,300,000 $ 231,100,000 $ 111,800,000
Company Selected Measure Amount 1,628,900,000 1,401,200,000 1,077,300,000 741,600,000
PEO Name Dr. Morrissey      
Additional 402(v) Disclosure Represents the company’s cumulative TSR. Cumulative TSR is calculated by dividing (i) the sum of (a) the cumulative amount
of dividends for the measurement period, assuming dividend reinvestment, and (b) the difference between our share price at
the end and the beginning of the measurement period, by (ii) our share price at the beginning of the measurement period.
The beginning of the measurement period for each year in the table is January 3, 2020. Cumulative TSR is calculated
assuming an investment of $100 in our common stock on January 3, 2020.
SEC rules require us to designate a “Company-Selected Measure” that in our assessment represents the most important
financial performance measure used by us to link the compensation actually paid to our PEO and non-PEO NEOs, for the most
recently completed fiscal year, to our performance. We have selected Net Product Revenues as this measure. 		     
Measure:: 1        
Pay vs Performance Disclosure        
Name Relative TSR      
Measure:: 2        
Pay vs Performance Disclosure        
Name Net Product Revenues      
PEO | Equity Awards Excluded [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ (14,259,313)      
PEO | Equity Awards Included [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 29,538,760      
PEO | Equity Awards Granted During The Year, Unvested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 18,468,346      
PEO | Equity Awards Granted In Prior Years, Unvested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 8,239,747      
PEO | Equity Awards Granted During The Year, Vested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 0      
PEO | Equity Awards Granted In Prior Years, Vested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 2,830,667      
PEO | Equity Awards Forfeited During The Year [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 0      
Non-PEO NEO | Equity Awards Excluded [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (4,571,569)      
Non-PEO NEO | Equity Awards Included [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 6,870,687      
Adjustment To Compensation Amount, Equity Awards 6,870,687      
Non-PEO NEO | Equity Awards Granted During The Year, Unvested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 5,152,448      
Non-PEO NEO | Equity Awards Granted In Prior Years, Unvested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 1,717,856      
Non-PEO NEO | Equity Awards Granted During The Year, Vested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 0      
Non-PEO NEO | Equity Awards Granted In Prior Years, Vested [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards 525,908      
Non-PEO NEO | Equity Awards Forfeited During The Year [Member]        
Pay vs Performance Disclosure        
Adjustment To Compensation Amount, Equity Awards $ (525,525)