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Collaboration Agreements And Business Development Activities - Other Collaborations Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
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Jan. 03, 2025 | Dec. 29, 2023 | Dec. 30, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenues | $ 2,168,701 | $ 1,830,208 | $ 1,611,062
Research and development | 910,408 | 1,044,071 | 891,813
Collaborative Arrangement with Genentech | Cotellic |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenues | 13,600 | 16,900 | 12,500
Research Collaborations, In-Licensing Arrangements and Other Business Development Activities |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Research and development | 69,200 | $ 173,000 | $ 203,900
Collaborative arrangement, maximum aggregate development milestone payments | 441,500 |  |
Potential regulatory milestone payments | 278,000 |  |
Collaborative arrangement, rights and obligations, maximum aggregate commercial milestone payments | $ 2,400,000 |  |

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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 48 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482785/280-10-55-48 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 985 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481283/985-20-50-2 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 730 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482916/730-10-50-1 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 912 -SubTopic 730 -Name Accounting Standards Codification -Section 25 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479532/912-730-25-1 + Details
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