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Stockholders’ Equity - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended				3 Months Ended			6 Months Ended	12 Months Ended
	May 30, 2024	Feb. 29, 2024	Apr. 30, 2023	Mar. 31, 2022	Mar. 31, 2021	Sep. 29, 2023	Mar. 31, 2023	Oct. 01, 2021	Jun. 28, 2024	Jan. 03, 2025	Dec. 29, 2023	Dec. 30, 2022	Jan. 01, 2021	Jan. 03, 2020	Aug. 31, 2024	Jan. 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Maximum potential to vest						50.00%		25.00%		175.00%
Number of shares earned (in shares)										1,500,000
Repurchases of common stock										$ 661,229	$ 554,870
January 2024 Repurchase Program
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock repurchase program, authorized amount																$ 450,000
Repurchases of common stock (in shares)									20,300,000
Repurchases of common stock									$ 450,000
August 2024 Repurchase Program
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock repurchase program, authorized amount															$ 500,000
Repurchases of common stock (in shares)										6,100,000
Repurchases of common stock										$ 205,600
Stock repurchase program, remaining authorized repurchase amount										294,400
Exelixis 401(k) Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expenses relating to stock match										$ 15,000	13,900	$ 11,700
Share-based Payment Arrangement, Tranche Two
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period				1 year
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of months following change in control in which an employee was terminated										3 months
Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of months following change in control in which an employee was terminated										15 months
Stock options
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expiration period										7 years
Total unrecognized compensation expense										$ 3,900
Unrecognized compensation expense weighted-average period for recognition										1 year 7 months 6 days
Intrinsic value of options exercised										$ 16,700	16,700	36,500
Cash received from option exercises and purchases under the ESPP										$ 49,600	$ 20,800	$ 13,900
Stock options | Share-based Payment Arrangement, Employee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period										4 years
Stock options | Share-based Payment Arrangement, Nonemployee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period										1 year
Restricted stock units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total unrecognized compensation expense										$ 161,100
Unrecognized compensation expense weighted-average period for recognition										2 years 2 months 12 days
Number of awards granted (in shares)										5,974,000
Forfeited (in shares)										2,063,000
Restricted stock units | Share-based Payment Arrangement, Employee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period										4 years
Restricted stock units | Share-based Payment Arrangement, Nonemployee
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period										1 year
TSR-Based Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of awards granted (in shares)		1,300,000	800,000	1,000,000.0
Maximum potential to vest		175.00%	175.00%	175.00%						175.00%
TSR-Based Restricted Stock Units | Share-based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Vesting award percentage		50.00%	50.00%	50.00%
TSR-Based Restricted Stock Units | Share-based Payment Arrangement, Tranche Two
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period		1 year	1 year
Employee stock purchase plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares available for grant (in shares)										7,000,000.0
Discount rate from market value on purchase date (as a percent)										85.00%
Discount rate from market value on offering date (as a percent)										85.00%
Purchase period										6 months
Common stock issued (in shares)										700,000	900,000	600,000
Average price per share (in dollars per share)										$ 18.23	$ 14.56	$ 16.63
Proceeds from employee stock purchase plan										$ 12,100	$ 12,700	$ 10,100
Performance stock units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Unrecognized compensation expense weighted-average period for recognition										1 month 6 days
Number of awards granted (in shares)					1,000,000.0					192,000
Maximum potential to vest					200.00%		100.00%	25.00%			125.00%		200.00%
Number of shares earned (in shares)											1,000,000.0
Forfeited (in shares)										2,733,000
Performance stock units | Probable
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total unrecognized compensation expense										$ 300
Performance stock units | Share-based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Vesting award percentage					50.00%
Performance stock units | Share-based Payment Arrangement, Tranche Two
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period					1 year
Performance Shares, Clinical Trial Results
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of awards granted (in shares)														2,300,000
Performance Shares, Performance Conditions Not Met
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Forfeited (in shares)										1,600,000
Amended and Restated 2017 Equity Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares available for grant (in shares)										28,600,000
Reduction in share reserve after stock option or stock appreciation award (in shares)										1
Reduction in share reserve after all other awards (in shares)										2
Amended And Restated 2000 Employee Stock Purchase Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Increase in share reserve under 2000 ESPP plan (in shares)	6,000,000

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