<SEC-DOCUMENT>0000939767-25-000045.txt : 20250228
<SEC-HEADER>0000939767-25-000045.hdr.sgml : 20250228
<ACCEPTANCE-DATETIME>20250228203548
ACCESSION NUMBER:		0000939767-25-000045
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250227
FILED AS OF DATE:		20250228
DATE AS OF CHANGE:		20250228

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Smith Julie
		CENTRAL INDEX KEY:			0001557928
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		25693265

	MAIL ADDRESS:	
		STREET 1:		C/O RAPTOR PHARMACEUTICAL CORP
		STREET 2:		9 COMMERCIAL BLVD, SUITE 200
		CITY:			NOVATO
		STATE:			CA
		ZIP:			94949

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0103

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1740792942.xml
<DESCRIPTION>FORM 4
<TEXT>
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    <periodOfReport>2025-02-27</periodOfReport>

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    <issuer>
        <issuerCik>0000939767</issuerCik>
        <issuerName>EXELIXIS, INC.</issuerName>
        <issuerTradingSymbol>EXEL</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>Smith Julie</rptOwnerName>
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            <rptOwnerStreet1>C/O EXELIXIS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1851 HARBOR BAY PARKWAY</rptOwnerStreet2>
            <rptOwnerCity>ALAMEDA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94502</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isTenPercentOwner>0</isTenPercentOwner>
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    <aff10b5One>0</aff10b5One>

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                <directOrIndirectOwnership>
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        <nonDerivativeTransaction>
            <securityTitle>
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        </nonDerivativeTransaction>
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    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>20.50</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2025-02-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>31167</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2018-05-24</value>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-05-23</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>31167</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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            </transactionDate>
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                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>23347</value>
                </transactionShares>
                <transactionPricePerShare>
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                    <value>D</value>
                </transactionAcquiredDisposedCode>
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            <exerciseDate>
                <value>2019-05-23</value>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2026-05-22</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>23347</value>
                </underlyingSecurityShares>
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                <sharesOwnedFollowingTransaction>
                    <value>19294</value>
                </sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
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                </directOrIndirectOwnership>
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            </transactionDate>
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            <exerciseDate>
                <value>2019-05-23</value>
                <footnoteId id="F4"/>
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                <value>2026-05-22</value>
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                <underlyingSecurityTitle>
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                <underlyingSecurityShares>
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    <footnotes>
        <footnote id="F1">Includes 10,015 shares of Exelixis, Inc. common stock (&quot;Common Stock&quot;) that will be issued to the Reporting Person upon vesting of restricted stock units (&quot;RSUs&quot;). Each RSU is the economic
equivalent of one share of Common Stock.</footnote>
        <footnote id="F2">Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $37.75 to $38.37. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 2 to this Form 4.</footnote>
        <footnote id="F3">The option, representing the right to purchase a total of 31,167 shares of Common Stock, became fully exercisable on May 24, 2018.</footnote>
        <footnote id="F4">The option, representing the right to purchase a total of 42,641 shares of Common Stock, became fully exercisable on May 23, 2019.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Nina Ayer, Attorney in Fact</signatureName>
        <signatureDate>2025-02-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
