<SEC-DOCUMENT>0000939767-25-000079.txt : 20250516
<SEC-HEADER>0000939767-25-000079.hdr.sgml : 20250516
<ACCEPTANCE-DATETIME>20250516205739
ACCESSION NUMBER:		0000939767-25-000079
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250514
FILED AS OF DATE:		20250516
DATE AS OF CHANGE:		20250516

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MORRISSEY MICHAEL
		CENTRAL INDEX KEY:			0001202096
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		25961286

	MAIL ADDRESS:	
		STREET 1:		C/O EXELIXIS INC
		STREET 2:		170 HARBOR WAY
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94083

	FORMER NAME:	
		FORMER CONFORMED NAME:	MORRISSEY MICHAEL M
		DATE OF NAME CHANGE:	20030512

	FORMER NAME:	
		FORMER CONFORMED NAME:	MORRISSEY MICHAEL R
		DATE OF NAME CHANGE:	20021029

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0102

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1747443453.xml
<DESCRIPTION>FORM 4
<TEXT>
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    <periodOfReport>2025-05-14</periodOfReport>

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    <issuer>
        <issuerCik>0000939767</issuerCik>
        <issuerName>EXELIXIS, INC.</issuerName>
        <issuerTradingSymbol>EXEL</issuerTradingSymbol>
    </issuer>

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        <reportingOwnerId>
            <rptOwnerCik>0001202096</rptOwnerCik>
            <rptOwnerName>MORRISSEY MICHAEL</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EXELIXIS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1851 HARBOR BAY PARKWAY</rptOwnerStreet2>
            <rptOwnerCity>ALAMEDA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94502</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President and CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
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                <value>Common Stock</value>
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            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>308365</value>
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                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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                <transactionCode>F</transactionCode>
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                <transactionAcquiredDisposedCode>
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                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
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            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>G</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F4"/>
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            <transactionAmounts>
                <transactionShares>
                    <value>87871</value>
                </transactionShares>
                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                    <footnoteId id="F1"/>
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                <directOrIndirectOwnership>
                    <value>D</value>
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        <nonDerivativeTransaction>
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                <value>Common Stock</value>
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                <value>2025-05-16</value>
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                <transactionPricePerShare>
                    <value>0</value>
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                    <value>A</value>
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                    <value>1852856</value>
                    <footnoteId id="F5"/>
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                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
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                    <footnoteId id="F6"/>
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                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By 401(k)</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>18.80</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2025-05-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>308365</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2019-09-10</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-09-09</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
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                    <value>308365</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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                    <value>0</value>
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        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Includes 1,416,692 shares of Exelixis, Inc. common stock (&quot;Common Stock&quot;) that will be issued to the Reporting Person upon vesting of restricted stock units (&quot;RSUs&quot;) and performance-based
restricted stock units (&quot;PSUs&quot;). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.</footnote>
        <footnote id="F2">Represents a &quot;net exercise&quot; of an outstanding stock option to purchase 308,365 shares, and pursuant to which the Reporting Person received 87,871 shares, of Common Stock. The Issuer withheld 220,494 shares of Common Stock underlying the stock option for payment of the exercise price and tax withholding using the closing stock price on May 14, 2025 of $44.65.</footnote>
        <footnote id="F3">Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded on March 4, 2022, April 3, 2023, and February 23, 2024.</footnote>
        <footnote id="F4">On May 16, 2025, the Reporting Person gifted 87,871 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.</footnote>
        <footnote id="F5">Shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.</footnote>
        <footnote id="F6">Represents shares of Common Stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of May 14, 2025.</footnote>
        <footnote id="F7">The option, representing the right to purchase a total of 308,365 shares of Common Stock, became fully exercisable on September 10, 2022.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Nina Ayer, Attorney in Fact</signatureName>
        <signatureDate>2025-05-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
