<SEC-DOCUMENT>0001972362-25-000509.txt : 20250521
<SEC-HEADER>0001972362-25-000509.hdr.sgml : 20250521
<ACCEPTANCE-DATETIME>20250521160842
ACCESSION NUMBER:		0001972362-25-000509
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250521
DATE AS OF CHANGE:		20250521

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0102

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		25973205

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Heyman Tomas J.
		CENTRAL INDEX KEY:			0001814673
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O AKERO THERAPEUTICS, INC.
		STREET 2:		170 HARBOR WAY 3RD FLOOR
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001814673</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000939767</issuerCik>
      <issuerName>EXELIXIS, INC.</issuerName>
      <secFileNumber>000-30235</secFileNumber>
      <issuerAddress>
        <com:street1>1851 HARBOR BAY PARKWAY</com:street1>
        <com:city>ALAMEDA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94502</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6508377000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Heyman Tomas J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Services</name>
        <address>
          <com:street1>1 NEW YORK PLAZA, 8TH FLOOR</com:street1>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>4544</noOfUnitsSold>
      <aggregateMarketValue>201259.21</aggregateMarketValue>
      <noOfUnitsOutstanding>272708280</noOfUnitsOutstanding>
      <approxSaleDate>05/21/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/31/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4544</amountOfSecuritiesAcquired>
      <paymentDate>05/31/2024</paymentDate>
      <natureOfPayment>NOT APPLICABLE</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/21/2025</noticeDate>
      <signature>/s/ Tom J Heyman</signature>
    </noticeSignature>
  </formData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
