<SEC-DOCUMENT>0000939767-25-000144.txt : 20251212
<SEC-HEADER>0000939767-25-000144.hdr.sgml : 20251212
<ACCEPTANCE-DATETIME>20251212180821
ACCESSION NUMBER:		0000939767-25-000144
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251212
DATE AS OF CHANGE:		20251212

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0102

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		251569373

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Haley Patrick J.
		CENTRAL INDEX KEY:			0001692954
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O EXELIXIS, INC.
		STREET 2:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001692954</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
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      <liveTestFlag>LIVE</liveTestFlag>



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  <formData>
    <issuerInfo>
      <issuerCik>0000939767</issuerCik>
      <issuerName>EXELIXIS, INC.</issuerName>
      <secFileNumber>000-30235</secFileNumber>
      <issuerAddress>
        <com:street1>1851 HARBOR BAY PARKWAY</com:street1>
        <com:city>ALAMEDA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94502</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6508377000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Haley Patrick J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Member of immediate family of any of the foregoing</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Investments</name>
        <address>
          <com:street1>PO Box 770001</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45277</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10648</noOfUnitsSold>
      <aggregateMarketValue>444873.44</aggregateMarketValue>
      <noOfUnitsOutstanding>268112157</noOfUnitsOutstanding>
      <approxSaleDate>11/20/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Bank of America/Merrill Lynch</name>
        <address>
          <com:street1>One Bryant Park</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>23539</noOfUnitsSold>
      <aggregateMarketValue>983459.42</aggregateMarketValue>
      <noOfUnitsOutstanding>268112157</noOfUnitsOutstanding>
      <approxSaleDate>11/20/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Bank of America/Merrill Lynch</name>
        <address>
          <com:street1>One Bryant Park</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>28043</noOfUnitsSold>
      <aggregateMarketValue>1192107.93</aggregateMarketValue>
      <noOfUnitsOutstanding>268112157</noOfUnitsOutstanding>
      <approxSaleDate>11/21/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/13/2015</acquiredDate>
      <natureOfAcquisitionTransaction>Open market purchases</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Open Market</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>51582</amountOfSecuritiesAcquired>
      <paymentDate>11/13/2015</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/22/2019</acquiredDate>
      <natureOfAcquisitionTransaction>401(k) matching shares</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10648</amountOfSecuritiesAcquired>
      <paymentDate>03/22/2019</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/12/2025</noticeDate>
      <signature>/s/ PJ Haley</signature>
    </noticeSignature>
  </formData>
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</SEC-DOCUMENT>
