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Supplemental Balance Sheet Information - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2020	[1]
Inventory [Line Items]
Inventory	$ 710,975		$ 710,975		$ 698,548
Depreciation expense, net of amounts capitalized into inventory	11,800	$ 9,700	24,300	$ 20,000
Vosoritide
Inventory [Line Items]
Inventory	$ 9,600		$ 9,600
[1] (1)December 31, 2020 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on February 26, 2021.

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