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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Net Product Revenues by Product (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenue from External Customer [Line Items]
Revenue	$ 501,693	$ 429,485	$ 987,723	$ 931,554
Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	171,655	116,695	329,953	253,898
Naglazyme | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	118,813	81,006	226,149	195,262
Kuvan | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	78,807	122,611	149,570	244,611
Palynziq | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	58,935	40,630	112,973	75,262
Brineura | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	30,332	25,798	57,657	49,768
Firdapse | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	0	0	0	1,316
Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	458,542	386,740	876,302	820,117
Aldurazyme | Marketed by Genzyme
Revenue from External Customer [Line Items]
Revenue	28,128	32,292	78,137	87,958
Total net product revenues
Revenue from External Customer [Line Items]
Revenue	$ 486,670	$ 419,032	$ 954,439	$ 908,075

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