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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Total Net Product Revenues Based on Patient Location (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Disaggregation of Revenue [Line Items]
Revenue	$ 501,693	$ 429,485	$ 987,723	$ 931,554
Europe
Disaggregation of Revenue [Line Items]
Revenue	172,678	109,259	334,519	254,295
United States
Disaggregation of Revenue [Line Items]
Revenue	204,245	232,552	412,431	476,724
Latin America
Disaggregation of Revenue [Line Items]
Revenue	42,248	37,864	101,953	97,788
Rest of world
Disaggregation of Revenue [Line Items]
Revenue	82,522	49,810	138,820	102,747
Total net product revenues
Disaggregation of Revenue [Line Items]
Revenue	486,670	419,032	954,439	908,075
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim
Disaggregation of Revenue [Line Items]
Revenue	458,542	386,740	876,302	820,117
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Europe
Disaggregation of Revenue [Line Items]
Revenue	166,704	104,319	315,576	245,170
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | United States
Disaggregation of Revenue [Line Items]
Revenue	169,411	197,171	324,474	378,842
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Latin America
Disaggregation of Revenue [Line Items]
Revenue	42,248	37,864	101,953	97,788
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Rest of world
Disaggregation of Revenue [Line Items]
Revenue	80,179	47,386	134,299	98,317
Marketed by Genzyme | Aldurazyme
Disaggregation of Revenue [Line Items]
Revenue	$ 28,128	$ 32,292	$ 78,137	$ 87,958

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