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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Net Product Revenues by Product (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Revenue from External Customer [Line Items] |  |  |  |
Revenue | $ 408,742 | $ 476,784 | $ 1,396,465 | $ 1,408,338
Vimizim | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 136,744 | 147,891 | 466,697 | 401,789
Naglazyme | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 71,172 | 76,323 | 297,321 | 271,585
Kuvan | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 67,687 | 123,993 | 217,257 | 368,604
Palynziq | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 60,729 | 46,092 | 173,702 | 121,354
Brineura | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 32,984 | 25,455 | 90,641 | 75,223
Voxzogo | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 144 | 0 | 144 | 0
Firdapse | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 0 | 0 | 0 | 1,316
Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 369,460 | 419,754 | 1,245,762 | 1,239,871
Aldurazyme | Marketed by Genzyme |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 24,380 | 40,987 | 102,517 | 128,945
Total net product revenues |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | $ 393,840 | $ 460,741 | $ 1,348,279 | $ 1,368,816

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8906-108599 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 40 -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e9031-108599 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 41 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e9038-108599 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8933-108599 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130543-203045 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8736-108599 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8736-108599 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 42 -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e9054-108599 Reference 10: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130545-203045 Reference 11: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 924 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 11.L) -URI http://asc.fasb.org/extlink&oid=6472922&loc=d3e499488-122856 + Details
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