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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 | [1]
--- | --- | --- | ---
Commitments And Contingencies [Line Items] |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones | $ 708,800 |
Contingent liabilities | 63,400 |
Short-term contingent consideration | 48,187 | $ 0
Purchase commitments and other minimum contractual obligations | 107,700 |
Kuvan And Palynziq | Third Party |  |
Commitments And Contingencies [Line Items] |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones | 70,000 |
Early Stage Development Program | Third Party |  |
Commitments And Contingencies [Line Items] |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones | 405,500 |
Programs No Longer Being Developed | Third Party |  |
Commitments And Contingencies [Line Items] |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones | $ 233,300 |
[1] | (1)December 31, 2020 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on February 26, 2021.

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