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Supplemental Balance Sheet Information - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020	[1]
Inventory [Line Items]
Inventory	$ 749,406		$ 749,406		$ 698,548
Depreciation expense, net of amounts capitalized into inventory	11,400	$ 11,100	35,700	$ 31,100
Voxzogo
Inventory [Line Items]
Inventory	$ 4,800		$ 4,800
[1] (1)December 31, 2020 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on February 26, 2021.

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