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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Net Product Revenues by Product (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenue from External Customer [Line Items]
Revenue	$ 408,742	$ 476,784	$ 1,396,465	$ 1,408,338
Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	136,744	147,891	466,697	401,789
Naglazyme | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	71,172	76,323	297,321	271,585
Kuvan | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	67,687	123,993	217,257	368,604
Palynziq | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	60,729	46,092	173,702	121,354
Brineura | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	32,984	25,455	90,641	75,223
Voxzogo | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	144	0	144	0
Firdapse | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	0	0	0	1,316
Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	369,460	419,754	1,245,762	1,239,871
Aldurazyme | Marketed by Genzyme
Revenue from External Customer [Line Items]
Revenue	24,380	40,987	102,517	128,945
Total net product revenues
Revenue from External Customer [Line Items]
Revenue	$ 393,840	$ 460,741	$ 1,348,279	$ 1,368,816

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