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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Total Net Product Revenues Based on Patient Location (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Disaggregation of Revenue [Line Items]
Revenue	$ 408,742	$ 476,784	$ 1,396,465	$ 1,408,338
United States
Disaggregation of Revenue [Line Items]
Revenue	196,239	252,948	608,670	729,672
Europe
Disaggregation of Revenue [Line Items]
Revenue	115,497	121,158	450,016	375,453
Latin America
Disaggregation of Revenue [Line Items]
Revenue	38,958	44,064	140,911	141,852
Rest of world
Disaggregation of Revenue [Line Items]
Revenue	58,048	58,614	196,868	161,361
Total net product revenues
Disaggregation of Revenue [Line Items]
Revenue	393,840	460,741	1,348,279	1,368,816
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim
Disaggregation of Revenue [Line Items]
Revenue	369,460	419,754	1,245,762	1,239,871
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | United States
Disaggregation of Revenue [Line Items]
Revenue	166,554	203,892	491,028	582,734
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Europe
Disaggregation of Revenue [Line Items]
Revenue	108,568	115,548	424,144	360,718
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Latin America
Disaggregation of Revenue [Line Items]
Revenue	38,958	44,064	140,911	141,852
Marketed by Company | Brineura, Firdapse, Kuvan, Naglazyme, Palynziq, and Vimizim | Rest of world
Disaggregation of Revenue [Line Items]
Revenue	55,380	56,250	189,679	154,567
Marketed by Genzyme | Aldurazyme
Disaggregation of Revenue [Line Items]
Revenue	$ 24,380	$ 40,987	$ 102,517	$ 128,945

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