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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net income (loss) $ (6,182) $ 837,001
Adjustments to reconcile net income (loss) to net cash used in operating activities:    
Depreciation and amortization 82,053 77,814
Non-cash interest expense 3,114 14,766
Amortization of premium on investments 3,279 175
Stock-based compensation 153,372 142,125
Gain on sale of nonfinancial assets 0 (59,495)
Inventory reserves, net of stock-based compensation 0 75,609
Deferred income taxes (12,020) (854,199)
Unrealized foreign exchange (gain) loss (1,347) 9,082
Non-cash changes in the fair value of contingent consideration 6,254 1,352
Other (1,317) 388
Changes in operating assets and liabilities:    
Accounts receivable, net 65,513 (32,915)
Inventory (19,125) (73,310)
Other current assets 27,029 32,848
Other assets (407) (5,543)
Accounts payable and accrued liabilities (7,129) (76,174)
Other long-term liabilities 269 9,225
Net cash provided by operating activities 293,356 98,749
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of property, plant and equipment (66,840) (83,286)
Maturities and sales of investments 502,112 345,224
Purchases of available-for-sale securities (737,144) (369,942)
Proceeds from sale of nonfinancial assets 0 67,159
Purchase of intangible assets (8,026) (14,369)
Investment in convertible note 0 (8,709)
Other (994) (725)
Net cash used in investing activities (310,892) (64,648)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from exercises of awards under equity incentive plans 32,877 60,268
Taxes paid related to net share settlement of equity awards (44,428) (42,667)
Repurchase of common stock 0 (50,000)
Proceeds from convertible senior subordinated note offering, net 0 585,752
Principal repayments of financing leases (2,492) (6,080)
Other (401) 0
Net cash provided by (used in) financing activities (14,444) 547,273
Effect of exchange rate changes on cash (35) (3,145)
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS (32,015) 578,229
Cash and cash equivalents:    
Beginning of period 649,158 437,446
End of period 617,143 1,015,675
SUPPLEMENTAL CASH FLOW DISCLOSURES:    
Cash paid for income taxes 15,531 4,355
Cash paid for interest 6,673 5,615
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:    
Decrease in accounts payable and accrued liabilities related to fixed assets (7,690) (13,281)
Increase (decrease) in accounts payable and accrued liabilities related to intangible assets $ 9,389 $ (3,043)