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PROPERTY, PLANT AND EQUIPMENT | 12 Months Ended
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Dec. 31, 2021
Property, Plant and Equipment [Abstract] |
PROPERTY, PLANT AND EQUIPMENT | PROPERTY, PLANT AND EQUIPMENT Property, Plant and Equipment, Net, consisted of the following:
| December 31,
| 2021 |  | 2020
Building and improvements | $ | 774,923 |  |  | $ | 761,560 |
Manufacturing and laboratory equipment | 444,182 |  |  | 414,439 |
Computer hardware and software | 201,382 |  |  | 189,740 |
Land | 90,418 |  |  | 90,418 |
Leasehold improvements | 55,279 |  |  | 55,134 |
Furniture and equipment | 42,976 |  |  | 40,223 |
Land improvements | 10,132 |  |  | 7,412 |
Construction-in-progress | 136,743 |  |  | 109,140 |
| 1,756,035 |  |  | 1,668,066 |
Accumulated depreciation | (720,574) |  |  | (635,595) |
Total property, plant and equipment, net | $ | 1,035,461 |  |  | $ | 1,032,471 |
Depreciation expense, net of amounts capitalized into inventory, was $46.1 million, $43.0 million and $51.8 million for the years ended December 31, 2021, 2020 and 2019, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=120429125&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99779-112916 + Details
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