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REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables) | 12 Months Ended
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Dec. 31, 2021
Risks and Uncertainties [Abstract] |
Disaggregates of Total Net Product Revenues from External Customers by Product | The following table presents Total Revenues and disaggregates Net Product Revenues by product.
| Years Ended December 31,
| 2021 |  | 2020 |  | 2019
Net product revenues by product: |  |  |  |  |
Vimizim | $ | 623,145 |  |  | $ | 544,257 |  |  | $ | 544,345 |
Naglazyme | 380,449 |  |  | 391,298 |  |  | 374,334 |
Kuvan | 285,776 |  |  | 457,736 |  |  | 463,353 |
Palynziq | 237,474 |  |  | 170,983 |  |  | 86,857 |
Brineura | 128,034 |  |  | 110,192 |  |  | 71,997 |
Voxzogo | 5,855 |  |  | — |  |  | — |
Firdapse | — |  |  | 1,288 |  |  | 22,348 |
Total net product revenues marketed by the Company | 1,660,733 |  |  | 1,675,754 |  |  | 1,563,234 |
Aldurazyme net product revenues marketed by Sanofi | 122,765 |  |  | 130,107 |  |  | 97,809 |
Total net product revenues | 1,783,498 |  |  | 1,805,861 |  |  | 1,661,043 |
Royalty and other revenues | 62,777 |  |  | 54,594 |  |  | 43,005 |
Total revenues | $ | 1,846,275 |  |  | $ | 1,860,455 |  |  | $ | 1,704,048 |
Disaggregates of Total Net Product Revenues Based on Patient Location | The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for Aldurazyme, which is sold exclusively by Sanofi worldwide.
| Years Ended December 31,
| 2021 |  | 2020 |  | 2019
United States | $ | 657,700 |  |  | $ | 756,863 |  |  | $ | 669,171 |
Europe | 558,952 |  |  | 498,725 |  |  | 485,596 |
Latin America | 191,151 |  |  | 205,862 |  |  | 218,792 |
Rest of world | 252,930 |  |  | 214,304 |  |  | 189,675 |
Total net product revenues marketed by the Company | 1,660,733 |  |  | 1,675,754 |  |  | 1,563,234 |
Aldurazyme net product revenues marketed by Sanofi | 122,765 |  |  | 130,107 |  |  | 97,809 |
Total net product revenues | $ | 1,783,498 |  |  | $ | 1,805,861 |  |  | $ | 1,661,043 |
Total Net Product Revenue Concentrations Attributed to Largest Customers | The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.
| Years Ended December 31,
| 2021 |  | 2020 |  | 2019
Customer A | 18 | % |  | 16 | % |  | 17 | %
Customer B | 14 | % |  | 15 | % |  | 13 | %
Customer C | 10 | % |  | 12 | % |  | 11 | %
Total | 42 | % |  | 43 | % |  | 41 | %
Summary of Non-Monetary Long-Lived Assets by Geographic Region | Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.
| December 31,
| 2021 |  | 2020
Long-lived assets by geography: |  |  |
United States | $ | 763,847 |  |  | $ | 771,286 |
Ireland | 304,748 |  |  | 300,555 |
Rest of world | 13,284 |  |  | 17,739 |
Total long-lived assets | $ | 1,081,879 |  |  | $ | 1,089,580 |

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