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LICENSE AND COLLABORATION AGREEMENTS - Additional Information (Detail) $ in Thousands, € in Millions | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Oct. 31, 2019 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2021 EUR (€) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2021 EUR (€) | Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Revenue |  | $ 1,846,275 |  | $ 1,860,455 | $ 1,704,048 |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones |  | 788,500 |  |  |  |  |
Firdapse | Disposal Group, Disposed of by Sale, Not Discontinued Operations |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Royalties on net product sales |  |  |  |  |  |  | 7.00%
Royalties on net product sales |  |  |  |  |  |  | 10.00%
Merck Serono |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones |  | 68,100 |  |  |  |  |
Exclusive Licensing Agreement For Tralesinidase Alfa |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Revenue | $ 3,000 |  |  |  |  |  |
Investment in equity |  | $ 12,600 |  |  |  |  |
Exclusive Licensing Agreement For Tralesinidase Alfa | Variable Interest Entity, Not Primary Beneficiary |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Minority equity ownership | 15.00% |  |  |  |  |  |
A&R Kuvan Agreement | Merck Serono | Maximum |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Business acquisition contingent consideration potential cash payments upon achievement of sales milestone | € |  |  |  |  |  | € 60.0 |
Pegvaliase Agreement | Merck Serono |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Business acquisition, cash paid | € |  |  | € 125.0 |  |  |  |

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