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PROPERTY, PLANT AND EQUIPMENT
 12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
PROPERTY, PLANT AND EQUIPMENT PROPERTY, PLANT AND EQUIPMENT
Property, Plant and Equipment, Net, consisted of the following:
December 31,
20212020
Building and improvements$774,923 $761,560 
Manufacturing and laboratory equipment444,182 414,439 
Computer hardware and software201,382 189,740 
Land90,418 90,418 
Leasehold improvements55,279 55,134 
Furniture and equipment42,976 40,223 
Land improvements10,132 7,412 
Construction-in-progress136,743 109,140 
1,756,035 1,668,066 
Accumulated depreciation(720,574)(635,595)
Total property, plant and equipment, net$1,035,461 $1,032,471 
Depreciation expense, net of amounts capitalized into inventory, was $46.1 million, $43.0 million and $51.8 million for the years ended December 31, 2021, 2020 and 2019, respectively.