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INVENTORY - Narrative (Details) - USD ($)
Dec. 31, 2021
Dec. 31, 2020
Inventory [Line Items]    
Inventory $ 776,669,000 $ 698,548,000
Pre-Launch Valoctocogene Roxaparvovec    
Inventory [Line Items]    
Inventory 0 0
Inventory valuation reserves $ 24,300,000 $ 87,200,000