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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Total Net Product Revenues Based on Patient Location (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation of Revenue [Line Items]
Revenue	$ 519,359	$ 486,030
Product
Disaggregation of Revenue [Line Items]
Revenue	505,525	467,769
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim
Disaggregation of Revenue [Line Items]
Revenue	481,143	417,760
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Europe
Disaggregation of Revenue [Line Items]
Revenue	156,832	148,872
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | United States
Disaggregation of Revenue [Line Items]
Revenue	150,815	155,064
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Middle East
Disaggregation of Revenue [Line Items]
Revenue	65,607	15,559
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Latin America
Disaggregation of Revenue [Line Items]
Revenue	62,544	59,705
Marketed by Company | Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Rest of world
Disaggregation of Revenue [Line Items]
Revenue	45,345	38,560
Marketed by Sanofi | Aldurazyme
Disaggregation of Revenue [Line Items]
Revenue	$ 24,382	$ 50,009

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