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Supplemental Financial Statements Information - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	[1]
Inventory [Line Items]
Inventory	$ 786,356		$ 776,669
Depreciation expense, net of amounts capitalized into inventory	11,700	$ 12,500
Gain on sale of nonfinancial assets, net	108,000	$ 0
Valoctocogene Roxaparvovec
Inventory [Line Items]
Inventory	$ 11,300
[1] (1)December 31, 2021 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on February 25, 2022.

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