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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Net Product Revenues by Product (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Revenue from External Customer [Line Items] |  |  |  |
Revenue | $ 533,798 | $ 501,693 | $ 1,053,157 | $ 987,723
Product |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 517,660 | 486,670 | 1,023,185 | 954,439
Vimizim | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 173,206 | 171,655 | 356,265 | 329,953
Naglazyme | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 115,783 | 118,813 | 243,814 | 226,149
Palynziq | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 61,643 | 58,935 | 116,528 | 112,973
Kuvan | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 57,602 | 78,807 | 116,939 | 149,570
Brineura | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 37,725 | 30,332 | 73,898 | 57,657
Voxzogo | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 34,374 | 0 | 54,032 | 0
Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Marketed by Company |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 480,333 | 458,542 | 961,476 | 876,302
Aldurazyme | Marketed by Sanofi |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | 37,327 | 28,128 | 61,709 | 78,137
Royalty and other revenues |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Revenue | $ 16,138 | $ 15,023 | $ 29,972 | $ 33,284

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8906-108599 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 40 -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e9031-108599 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 41 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e9038-108599 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130543-203045 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8736-108599 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8736-108599 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 42 -URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e9054-108599 Reference 10: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130545-203045 Reference 11: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 924 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 11.L) -URI https://asc.fasb.org/extlink&oid=6472922&loc=d3e499488-122856 + Details
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