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Revenue, Credit Concentrations and Geographic Information - Disaggregates of Net Product Revenues by Product (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue from External Customer [Line Items]
Revenue	$ 533,798	$ 501,693	$ 1,053,157	$ 987,723
Product
Revenue from External Customer [Line Items]
Revenue	517,660	486,670	1,023,185	954,439
Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	173,206	171,655	356,265	329,953
Naglazyme | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	115,783	118,813	243,814	226,149
Palynziq | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	61,643	58,935	116,528	112,973
Kuvan | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	57,602	78,807	116,939	149,570
Brineura | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	37,725	30,332	73,898	57,657
Voxzogo | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	34,374	0	54,032	0
Brineura, Kuvan, Naglazyme, Palynziq, and Vimizim | Marketed by Company
Revenue from External Customer [Line Items]
Revenue	480,333	458,542	961,476	876,302
Aldurazyme | Marketed by Sanofi
Revenue from External Customer [Line Items]
Revenue	37,327	28,128	61,709	78,137
Royalty and other revenues
Revenue from External Customer [Line Items]
Revenue	$ 16,138	$ 15,023	$ 29,972	$ 33,284

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