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BUSINESS OVERVIEW AND SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Details) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 USD ($) segment tranche | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Net income (loss) |  | $ 141,561 | $ (64,080) |  | $ 854,029 | [1],[2],[3] |
Accumulated deficit |  | 789,199 | 930,760 | [4] |  |  |
Stockholders' equity decrease |  | (4,603,156) | (4,265,669) | [4] | (4,100,931) |  | $ (3,122,381)
Deferred tax assets |  | 1,505,412 | 1,450,161 | [4] |  |  |
Other assets |  | 176,236 | 152,121 | [4] |  |  |
Decrease in other long-term liabilities |  | $ (100,015) | (98,362) | [4] |  |  |
Payment term after customer control |  | 1 year |  |  |  |  |
Period between customer control and payment |  | 1 year |  |  |  |  |
Advertising expenses |  | $ 25,200 | 30,200 |  | 29,300 |  |
Number of tranches in offering period | tranche |  | 4 |  |  |  |  |
Span of offering period |  | 24 months |  |  |  |  |
Foreign currency transaction losses |  | $ 11,400 | 11,700 |  | 9,900 |  |
Number of reportable segment | segment |  | 1 |  |  |  |  |
Number of operating segments | segment |  | 1 |  |  |  |  |
ALDURAZYME net product revenues marketed by Sanofi | Minimum |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Payment received as percentage of net product sales |  | 39.50% |  |  |  |  |
ALDURAZYME net product revenues marketed by Sanofi | Maximum |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Payment received as percentage of net product sales |  | 50.00% |  |  |  |  |
Revision of Prior Period, Error Correction, Adjustment |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Net income (loss) |  |  |  |  | (5,100) |  |
Accumulated deficit |  |  |  |  | 5,100 |  |
Accounts payable and accrued liabilities |  |  | 6,700 |  |  |  |
Stockholders' equity decrease | [5] |  | 5,071 |  | $ 5,071 |  | $ 0
Deferred tax assets |  |  | 1,100 |  |  |  |
Other assets |  |  | 400 |  |  |  |
Decrease in other long-term liabilities |  |  | $ 100 |  |  |  |
[1] | Certain December 31, 2020 balances have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.
[2] | Certain December 31, 2020 amounts have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.
[3] | December 31, 2020 Net Income has been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.
[4] | Certain December 31, 2021 balances have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.
[5] | The years ended December 31, 2021 and 2020 have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.

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