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PROPERTY, PLANT AND EQUIPMENT
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
PROPERTY, PLANT AND EQUIPMENT PROPERTY, PLANT AND EQUIPMENT
Property, Plant and Equipment, Net, consisted of the following:
December 31
20222021
Building and improvements$819,100 $774,923 
Manufacturing and laboratory equipment475,663 444,182 
Computer hardware and software214,829 201,382 
Land90,786 90,418 
Leasehold improvements59,532 55,279 
Furniture and equipment45,762 42,976 
Land improvements26,455 10,132 
Construction-in-progress143,384 136,743 
1,875,511 1,756,035 
Accumulated depreciation(802,145)(720,574)
Total property, plant and equipment, net$1,073,366 $1,035,461 
Depreciation expense, net of amounts capitalized into inventory, was $38.6 million, $46.1 million and $43.0 million for the years ended December 31, 2022, 2021 and 2020, respectively.