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REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables)

12 Months Ended

Dec. 31, 2022

Risks and Uncertainties [Abstract]

Schedule of Disaggregates of Total Net Product Revenues from External Customers by Product

The following table presents Total Revenues and disaggregates Net Product Revenues by product.

			Years Ended December 31,
			2022						2021						2020
Net product revenues by product:
VIMIZIM			$	663,739					$	623,145					$	544,257
NAGLAZYME			443,794						380,449						391,298
PALYNZIQ			255,032						237,474						170,983
KUVAN			227,577						285,776						457,736
VOXZOGO			169,128						5,855						—
BRINEURA			154,333						128,034						110,192
FIRDAPSE			—						—						1,288
Total net product revenues marketed by the Company			1,913,603						1,660,733						1,675,754
ALDURAZYME net product revenues marketed by Sanofi			128,422						122,765						130,107
Total net product revenues			2,042,025						1,783,498						1,805,861
Royalty and other revenues			54,014						62,777						54,594
Total revenues			$	2,096,039					$	1,846,275					$	1,860,455

Schedule of Disaggregates of Total Net Product Revenues Based on Patient Location

The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is sold exclusively by Sanofi worldwide.

			Years Ended December 31,
			2022						2021						2020
United States			$	684,284					$	657,700					$	756,863
Europe			650,952						558,952						498,725
Latin America			266,801						191,151						205,862
Rest of world			311,566						252,930						214,304
Total net product revenues marketed by the Company			1,913,603						1,660,733						1,675,754
ALDURAZYME net product revenues marketed by Sanofi			128,422						122,765						130,107
Total net product revenues			$	2,042,025					$	1,783,498					$	1,805,861

Schedule of Total Net Product Revenue Concentrations Attributed to Largest Customers

The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.

			Years Ended December 31,
			2022						2021						2020
Customer A			16		%				18		%				16		%
Customer B			12		%				14		%				15		%
Customer C			9		%				10		%				12		%
Total			37		%				42		%				43		%

Schedule of Non-Monetary Long-Lived Assets by Geographic Region

Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.

			December 31,
			2022						2021
Long-lived assets by geography:
United States			$	786,509					$	763,847
Ireland			309,180						304,748
Rest of world			18,633						13,284
Total long-lived assets			$	1,114,322					$	1,081,879

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