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INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Provision for (Benefit from) Income Taxes Based on Income (Loss) Before Income Taxes

The Provision for (Benefit from) Income Taxes was based on Income (Loss) before Income Taxes as follows:

			Years Ended December 31,
			2022						2021						2020 (1)
U.S. Source			$	(299,403)					$	(259,258)					$	(169,614)
Non-U.S. Source			448,979						183,908						120,617
Income (loss) before income taxes			$	149,576					$	(75,350)					$	(48,997)

Schedule of Components of Provision for (Benefit From) Income Taxes

The U.S. and foreign components of the Provision for (Benefit from) Income Taxes were as follows:

			Years Ended December 31,
			2022						2021						2020 (1)
Provision for (benefit from) income taxes
Federal			$	12,798					$	(2,038)					$	(15,073)
State and local			5,058						1,339						998
Foreign			42,246						5,037						1,042
			60,102						4,338						(13,033)
Provision for (benefit from) deferred income taxes:
Federal			(79,270)						(29,895)						(46,124)
State and local			(5,143)						(1,230)						(5,321)
Foreign			32,326						15,517						(838,548)
			(52,087)						(15,608)						(889,993)
Provision for (benefit from) income taxes			$	8,015					$	(11,270)					$	(903,026)

(1)Certain December 31, 2020 amounts have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.

Schedule of Reconciliation of Statutory Federal Income Tax Rate to Company's Effective Income Tax Rate

The following is a reconciliation of the statutory federal income tax benefit to the Company’s effective tax rate:

			December 31,
			2022						2021						2020 (3)
Federal statutory income tax rate			$	31,412					$	(15,824)					$	(10,289)
State and local taxes			(1,017)						509						(3,467)
Orphan Drug & General Business Credit			(35,674)						(29,363)						(44,114)
Stock compensation expense			6,433						7,859						(1,101)
Foreign Source Income Subject to US Tax			(5,644)						16,878						6,266
Foreign tax rate differential (1) (2)			(4,051)						(16,971)						(16,238)
Section 162(m) limitation			6,577						6,304						9,571
Tax Reserves			18,043						15,530						2,166
Intra-entity transfer of assets			(18,752)						(3,920)						(852,338)
CARES act carryback claim			—						—						(2,201)
Valuation allowance/deferred benefit			7,851						6,821						6,876
Other			2,837						907						1,843
Effective income tax rate			$	8,015					$	(11,270)					$	(903,026)

(1)For the year ended December 31, 2022, the foreign rate differential included foreign local tax expense which was at an effective rate lower than the U.S. statutory rate and is offset by the PRV income taxed at a higher tax rate.

(2)For the year ended December 31, 2021, the foreign rate differential included foreign local tax expense which was at an effective rate lower than the U.S. statutory rate and includes the recognition of the valuation allowance against a portion of the deferred tax assets of the Company’s Dutch subsidiary of $9.3 million.

(3)Certain December 31, 2020 amounts have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.

Schedule of Components of Net Deferred Tax Assets

The significant components of the Company’s net deferred tax assets were as follows:

			December 31,
			2022						2021
Net deferred tax assets:
Net operating loss carryforwards			$	20,657					$	25,936
Tax credit carryforwards (1)			555,319						564,109
Accrued expenses, reserves, and prepaids			88,697						72,759
Intangible assets			836,402						875,311
Capitalized research and development expenses			103,212						—
Stock-based compensation			49,472						50,910
Lease liabilities			5,757						7,422
Inventory			22,726						25,169
Other			5,596						1,942
Valuation allowance			(116,299)						(109,176)
Total deferred tax assets			1,571,539						1,514,382
Joint venture basis difference			(745)						(1,665)
Acquired intangibles			(1,138)						(1,250)
ROU Assets			(5,347)						(6,808)
Property, plant and equipment			(58,897)						(54,498)
Total deferred tax liabilities			(66,127)						(64,221)
Net deferred tax assets			$	1,505,412					$	1,450,161

(1)Certain December 31, 2021 amounts have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.

Schedule of Expiration of not Utilized Net Operating Loss and Tax Credit Carryforwards

As of December 31, 2022, the Company had the following net operating loss and tax credit carryforwards, which if not utilized, will expire as follows:

Type						Amount						Year
Federal net operating loss carryforwards						$	3,628					2030-2033
Federal R&D and orphan drug credit carryforwards						$	585,322					2024-2042
State net operating loss carryforwards						$	186,594					2023-2042
Dutch net operating loss carryforwards						$	38,912					Indefinite

Schedule of Reconciliation of Unrecognized Tax Benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits for the years ended December 31, 2022 and 2021, is as follows:

			December 31,
			2022						2021
Balance at beginning of period			$	205,095					$	182,564
Additions based on tax positions related to the current year			26,762						23,499
(Deletions) Additions for tax positions of prior years			1,017						(786)
Lapse of statute of limitations			(18)						(182)
Balance at end of period			$	232,856					$	205,095

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