INCOME TAXES - Summary of Expiration of not Utilized Net Operating Loss and Tax Credit Carryforwards (Details) $ in Thousands	Dec. 31, 2022 USD ($)
Federal
Income Tax Contingency [Line Items]
Net operating loss carryforwards	$ 3,628
Federal R&D and orphan drug credit carryforwards	585,322
State
Income Tax Contingency [Line Items]
Net operating loss carryforwards	186,594
Federal R&D and orphan drug credit carryforwards	152,700
Dutch \| Foreign
Income Tax Contingency [Line Items]
Net operating loss carryforwards, not subject to expiration	$ 38,912

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 8
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32632-109319

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32559-109319

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 6
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32621-109319

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Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant