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LICENSE AND COLLABORATION AGREEMENTS (Details) $ in Thousands, € in Millions	1 Months Ended	12 Months Ended
	Oct. 31, 2019 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 EUR (€)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	[1]	Dec. 31, 2022 EUR (€)	Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue | $		$ 2,096,039		$ 1,846,275	$ 1,860,455
Firdapse | Disposal Group, Disposed of by Sale, Not Discontinued Operations
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalties on net product sales								7.00%
Royalties on net product sales								10.00%
Exclusive Licensing Agreement For Tralesinidase Alfa
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue | $	$ 3,000
Investment in equity | $		$ 12,600
Exclusive Licensing Agreement For Tralesinidase Alfa | Variable Interest Entity, Not Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Minority equity ownership	15.00%
A&R Kuvan Agreement | Merck Serono
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent consideration | €							€ 15.0
A&R Kuvan Agreement | Merck Serono | Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition contingent consideration potential cash payments upon achievement of sales milestone | €							€ 60.0
Pegvaliase Agreement | Merck Serono
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition, cash paid | €			€ 125.0
[1] Certain December 31, 2020 amounts have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Consolidated Financial Statements for details.

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