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REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION | 12 Months Ended
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Dec. 31, 2023
Risks and Uncertainties [Abstract] |
REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION | REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION The following table presents Total Revenues and disaggregates Net Product Revenues by product.
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
Enzyme product revenues: |  |  |  |  |
VIMIZIM | $ | 701,053 |  |  | $ | 663,739 |  |  | $ | 623,145 |
NAGLAZYME | 420,292 |  |  | 443,794 |  |  | 380,449 |
PALYNZIQ | 303,919 |  |  | 255,032 |  |  | 237,474 |
BRINEURA | 161,889 |  |  | 154,333 |  |  | 128,034 |
ALDURAZYME | 131,248 |  |  | 128,422 |  |  | 122,765 |
Total enzyme product revenues | 1,718,401 |  |  | 1,645,320 |  |  | 1,491,867 |
VOXZOGO | 469,881 |  |  | 169,128 |  |  | 5,855 |
KUVAN | 180,767 |  |  | 227,577 |  |  | 285,776 |
ROCTAVIAN | 3,489 |  |  | — |  |  | — |
Total net product revenues | 2,372,538 |  |  | 2,042,025 |  |  | 1,783,498 |
Royalty and other revenues | 46,688 |  |  | 54,014 |  |  | 62,777 |
Total revenues | $ | 2,419,226 |  |  | $ | 2,096,039 |  |  | $ | 1,846,275 |
The Company considers there to be revenue concentration risks for regions where Net Product Revenues exceed 10% of consolidated Net Product Revenues. The concentration of the Company’s Net Product Revenues within the regions below may have a material adverse effect on the Company’s revenues and results of operations if sales in the respective regions experience difficulties. The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is distributed, marketed and sold exclusively by Sanofi worldwide.
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
United States | $ | 771,314 |  |  | $ | 684,284 |  |  | $ | 657,700 |
Europe | 669,331 |  |  | 650,952 |  |  | 558,952 |
Latin America | 332,437 |  |  | 266,801 |  |  | 191,151 |
Rest of world | 468,208 |  |  | 311,566 |  |  | 252,930 |
Total net product revenues marketed by the Company | 2,241,290 |  |  | 1,913,603 |  |  | 1,660,733 |
ALDURAZYME net product revenues marketed by Sanofi | 131,248 |  |  | 128,422 |  |  | 122,765 |
Total net product revenues | $ | 2,372,538 |  |  | $ | 2,042,025 |  |  | $ | 1,783,498 |
The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
Customer A | 14 | % |  | 16 | % |  | 18 | %
Customer B | 12 | % |  | 12 | % |  | 14 | %
Customer C | 10 | % |  | 9 | % |  | 10 | %
Total | 36 | % |  | 37 | % |  | 42 | %
On a consolidated basis, two customers accounted for 15% and 12% of the Company’s December 31, 2023 accounts receivable balance, respectively, compared to December 31, 2022 when two customers accounted for 22% and 15% of the accounts receivable balance, respectively. As of December 31, 2023 and 2022, the accounts receivable balance for Sanofi included $63.4 million and $68.8 million, respectively, of unbilled accounts receivable, which becomes payable to the Company when the product is sold through by Sanofi. The Company does not require collateral from its customers, but does perform periodic credit evaluations of its customers’ financial condition and requires prepayments in certain circumstances. The Company is mindful that conditions in the current macroeconomic environment, such as inflation, changes in interest and foreign currency exchange rates, natural disasters and supply chain disruptions, could affect the Company’s ability to achieve its goals. In addition, the Company sells its products in countries that face economic volatility and weakness. Although the Company has historically collected receivables from customers in certain countries, sustained weakness or further deterioration of the local economies and currencies may cause customers in those countries to delay payment or be unable to pay for the Company’s products. The Company believes that the allowances for doubtful accounts related to these countries, if any, are adequate based on its analysis of the specific business circumstances and expectations of collection for each of the underlying accounts in these countries. The Company will continue to monitor these conditions and will attempt to adjust its business processes, as appropriate, to mitigate macroeconomic risks to its business. Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.
| December 31,
| 2023 |  | 2022
Long-lived assets by geography: |  |  |
United States | $ | 788,590 |  |  | $ | 786,509 |
Ireland | 306,542 |  |  | 309,180 |
Rest of world | 17,075 |  |  | 18,633 |
Total long-lived assets | $ | 1,112,207 |  |  | $ | 1,114,322 |

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