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REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables)

12 Months Ended

Dec. 31, 2023

Risks and Uncertainties [Abstract]

Schedule of Total Revenues and Disaggregates Net Product Revenues by Product

The following table presents Total Revenues and disaggregates Net Product Revenues by product.

			Years Ended December 31,
			2023						2022						2021
Enzyme product revenues:
VIMIZIM			$	701,053					$	663,739					$	623,145
NAGLAZYME			420,292						443,794						380,449
PALYNZIQ			303,919						255,032						237,474
BRINEURA			161,889						154,333						128,034
ALDURAZYME			131,248						128,422						122,765
Total enzyme product revenues			1,718,401						1,645,320						1,491,867
VOXZOGO			469,881						169,128						5,855
KUVAN			180,767						227,577						285,776
ROCTAVIAN			3,489						—						—
Total net product revenues			2,372,538						2,042,025						1,783,498
Royalty and other revenues			46,688						54,014						62,777
Total revenues			$	2,419,226					$	2,096,039					$	1,846,275

Schedule of Disaggregation of Total Net Product Revenues by Geographic Region

The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is distributed, marketed and sold exclusively by Sanofi worldwide.

			Years Ended December 31,
			2023						2022						2021
United States			$	771,314					$	684,284					$	657,700
Europe			669,331						650,952						558,952
Latin America			332,437						266,801						191,151
Rest of world			468,208						311,566						252,930
Total net product revenues marketed by the Company			2,241,290						1,913,603						1,660,733
ALDURAZYME net product revenues marketed by Sanofi			131,248						128,422						122,765
Total net product revenues			$	2,372,538					$	2,042,025					$	1,783,498

Schedule of Total Net Product Revenues Attributed to Largest Customers

The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.

			Years Ended December 31,
			2023						2022						2021
Customer A			14		%				16		%				18		%
Customer B			12		%				12		%				14		%
Customer C			10		%				9		%				10		%
Total			36		%				37		%				42		%

Schedule of Long-Lived Assets by Geographic Region

Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.

			December 31,
			2023						2022
Long-lived assets by geography:
United States			$	788,590					$	786,509
Ireland			306,542						309,180
Rest of world			17,075						18,633
Total long-lived assets			$	1,112,207					$	1,114,322

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