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LICENSE AND COLLABORATION AGREEMENTS (Details) $ in Thousands, € in Millions	1 Months Ended	12 Months Ended
	Oct. 31, 2019 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2023 EUR (€)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue		$ 2,419,226		$ 2,096,039	$ 1,846,275
Impairment loss		10,538		2,050	$ (11,846)
FIRDAPSE | Disposal Group, Disposed of by Sale, Not Discontinued Operations
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalties on net product sales, minimum						7.00%
Royalties on net product sales, maximum						10.00%
Exclusive Licensing Agreement for Tralesinidase Alfa
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue	$ 3,000
Investment in equity				$ 12,600
Exclusive Licensing Agreement for Tralesinidase Alfa | Variable Interest Entity, Not Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Minority equity ownership	15.00%
A&R Kuvan Agreement | Merck Serono | Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition contingent consideration potential cash payments upon achievement of sales milestone | €			€ 60.0
Pegvaliase Agreement | Merck Serono
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition, cash paid | €			€ 125.0
Research and Collaboration Agreement With Third Party
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Impairment loss		$ 11,900

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