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SEGMENT INFORMATION - Summary of Reportable Segment Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Revenue from External Customer [Line Items]      
Total revenues $ 2,853,915 $ 2,419,226 $ 2,096,039
Cost of sales 580,235 532,062 503,023
Research and development 747,184 746,773 649,606
NET INCOME 426,859 167,645 141,561
Reportable Segment      
Revenue from External Customer [Line Items]      
Total revenues 2,853,915 2,419,226 2,096,039
Cost of sales 580,235 532,062 503,023
S&M expenses 476,739 488,442 450,349
G&A expenses 532,286 403,964 372,894
Other segment expense (income), net 90,612 80,340 (21,394)
NET INCOME 426,859 167,645 141,561
Research and early pipeline | Reportable Segment      
Revenue from External Customer [Line Items]      
Research and development 434,023 393,078 313,915
Later-stage clinical programs | Reportable Segment      
Revenue from External Customer [Line Items]      
Research and development 27,581 62,604 119,015
Later-stage clinical programs | Reportable Segment      
Revenue from External Customer [Line Items]      
Research and development $ 285,580 $ 291,091 $ 216,676