0001047469-05-006784 10-K 13 20041231 20050316 20050316 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 10-K 34 000-19125 05685991 2292 FARADAY AVE CARLSBAD CA 92008 7609319200 2292 FARADAY AVE CARLSBAD CA 92008 10-K 1 a2153640z10-k.htm FORM 10-K EX-10.52 2 a2153640zex-10_52.htm EXHIBIT 10.52 EX-10.53 3 a2153640zex-10_53.htm EXHIBIT 10.53 EX-10.54 4 a2153640zex-10_54.htm EXHIBIT 10.54 EX-10.55 5 a2153640zex-10_55.htm EXHIBIT 10.55 EX-10.56 6 a2153640zex-10_56.htm EXHIBIT 10.56 EX-10.57 7 a2153640zex-10_57.htm EXHIBIT 10.57 EX-10.58 8 a2153640zex-10_58.htm EXHIBIT 10.58 EX-21.1 9 a2153640zex-21_1.htm EXHIBIT 21.1 EX-23.1 10 a2153640zex-23_1.htm EXHIBIT 23.1 EX-31.1 11 a2153640zex-31_1.htm EXHIBIT 31.1 EX-31.2 12 a2153640zex-31_2.htm EXHIBIT 31.2 EX-32.1 13 a2153640zex-32_1.htm 3XHIBIT 32.1