0000874015-05-000008 4 1 20050103 20050104 20050104 MCNEIL JOHN A 0001181558 DE 1231 4 34 000-19125 05509234 2292 FARADAY AVENUE CARLSBAD CA 92008 7609319200 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 2292 FARADAY AVE CARLSBAD CA 92008 7609319200 2292 FARADAY AVE CARLSBAD CA 92008 4 1 edgar.xml PRIMARY DOCUMENT