0001104659-05-022141 10-Q 4 20050331 20050510 20050510 ISIS PHARMACEUTICALS INC 0000874015 2834 330336973 DE 1231 10-Q 34 000-19125 05816351 2292 FARADAY AVE CARLSBAD CA 92008 7609319200 2292 FARADAY AVE CARLSBAD CA 92008 10-Q 1 a05-8012_110q.htm 10-Q EX-31.1 2 a05-8012_1ex31d1.htm EX-31.1 EX-31.2 3 a05-8012_1ex31d2.htm EX-31.2 EX-32.1 4 a05-8012_1ex32d1.htm EX-32.1